If these occur, discontinue tirzepatide immediately and seek medical evaluation
These substances are theorised to enhance hepatic fat metabolism and support liver function
Its important to adjust treatment for each patient to make it work best
Doses above recommended levels have not been shown to cause harm
If you experience persistent headaches, fatigue, mood changes, and other symptoms that dont resolve within a few days, contact your prescribing clinician immediately to assess your condition and prevent possible complications
Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss