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GSTT1, GSTM1 and GSTP1 genetic polymorphisms and interaction with tobacco, alcohol and occupational exposure in esophageal cancer patients from North India

doi:10.1136/bmj.324.7352.1512 Song C, He J, Chen J, et al

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Post oxygen-glucose deprivation/reoxygenation (OGD/R), a marked reduction in SH-SY5Y cell viability was observed (Figure 4C)

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Due to the absence of histone protection and the proximity of mitochondrial DNA (mtDNA) to sites of ROS generation, the mutation rate of mtDNA can be 10 to 100 times higher than that of nuclear DNA