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Synthesis of 3,4- cis -leucocyanidin (6) Dihydroquercetin ( 10 ) at 5 mg ml 1 was reduced with NaBH 4 at 5 mg ml 1 in ethanol to form 3,4- trans -leucocyanidin ( 14 ) under vigorous stirring for 90 min at 23 C
Although oxidizing conditions are necessary in the cytosol, to allow optimum translocation and dissociation of NF-B from inhibitory IB (resulting in activation of NF-B), NF-B must be maintained in a reduced state in the nucleus for activation to occur [13, 14, 1619, 54, 55, 58, 62, 103, 104, 114116]
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