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In ovarian cancer, elevated HSP60 expression supports tumor progression by stabilizing mitochondrial homeostasis and activating the mTOR signaling pathway
Protects the Brain Where inflammation can greatly impair important body systems, such as the nervous and circulatory system, glutathiones antioxidant power may repair inflammatory cellular damage in the brain
doi: 10.1248/cpb.c17-00163 19 NguyenA-TFontaineJMalonneHClaeysMLuhmerMDuezP
PLGA nanoparticles coated with baicalin and the melanoma antigen Hgp peptide fragment 25-33, prepared using ultrasound double-emulsion technology and further loaded with CpG fragments and forming a nanocomposite on their surface with conjugated M2pep and -pep peptides, can be effectively taken up by M2 TAMs and convert M2-like TAMs into M1-like phenotypes thereby remodeling the TME and killing tumor cells (56)
As a comparative measure, pSiNP modified with bovine serum albumin (BSA@pSiNP) displayed analogous attributes, including size (172 4 nm) and zeta potential (-9.9 4.4 mV)