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6 weeks (200300 mcg/day): ~2 vials 8 weeks (200300 mcg/day): ~3 vials Advanced (250 mcg, 2/day): ~6 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks (once daily): ~56 syringes 8 weeks (twice daily): ~112 syringes Bacteriostatic Water (10 mL bottles) Use 3.0 mL (standard) or 2.0 mL (advanced) per 5 mg vial for reconstitution

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PBG, porphobilinogen

After library preparation and quality control, double-end sequencing was performed on the Illumina Nova Seq6000 sequencing platform in 2 150 bp mode