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Furthermore, HIF-1 reduces mitochondrial ROS production at its source by suppressing the expression and activity of mitochondrial respiratory chain complexes and activating glycolysis [135]

For example, inhibiting the activity of certain kinases can reduce the phosphorylation of mut-p53, thereby reducing its stability

PMID 8595136

8(2):757760.e4

Patterson RE, Sears DD (2017) Metabolic effects of intermittent fasting

Despite their potential to ameliorate neurodegeneration through upregulation of NRF2 and its target genes, as shown by numerous pre-clinical studies, their molecular off-target effects and concomitant unpredictable side-effects pose an obstacle for clinical trials and approval