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Additionally, H&E and Safranin-O/Fast green staining showed that metformin treatment did not significantly ameliorate cartilage degradation induced by MIA-induced OA in Nrf2 KO mice (Fig

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This drives S-phase entry through upregulation of ribosome biogenesis genes and cyclin-dependent kinases, accelerating proliferation while fostering genomic instability (Qiu et al., 2022)