Given that increased expression of immunological genes was detected, various cytokines (LEGENDplex, BioLegend) were detected via multiplex flow cytometry in copper-treated HepG2 and HepG2 ATP7B-KO cells
Superoxide dismutases in the lung and human lung diseases
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These healthspan improvement findings have profound implications for longevity research, development of geroprotective therapies, and understanding how senescent cell accumulation contributes to the functional decline characteristic of biological aging
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Similarly, PNPLA3 I148M promotes hepatosteatosis through ABHD5-dependent inhibition of PNPLA2 (75), suggesting that small molecules that target the PNPLA3 I148M/ABHD5 interaction could be potential therapeutics for FLD and diabetes
