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Studies have revealed that upon reaching the BBB, nanoparticles can cross via several mechanisms, including carrier-mediated, receptor-mediated, and adsorptive-mediated transcytosis, as well as passive diffusion, clathrin-mediated endocytosis, and micropinocytosis 59

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Ferritin could be degraded in lysosomes by ferritinophagy to increase free iron levels (Gammella et al., 2015

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By hitting these secondary endpoints so strongly against apremilast, Takeda is positioning zasocitinib to fundamentally disrupt the first-line oral and tier-preferred immunology market