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Lysyl oxidase activity is an enzyme responsible for cross-linking collagen fibrils into mechanically stable networks
Retatrutide is a triple agonist (GIP, GLP-1, and glucagon receptors) while Ozempic activates only GLP-1 receptors, resulting in significantly greater weight loss, 24.2% versus 14.9% at standard doses
Treatments are vehicle (V), CagriSema (CS, 2 + 2 nmol/kg), and calorie-restricted to match the weight of the CS rats (weight matched, WM)
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