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Studies indicate that skeletal muscle possesses the complete enzymatic machinery necessary to convert DHEA into testosterone and estradiol, including 3-hydroxysteroid dehydrogenase, 17-hydroxysteroid dehydrogenase, and aromatase enzymes

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Lipid peroxidations byproducts, such as 4-hydroxynonenal or malondialdehyde, can react with lysine amino groups, histidine imidazole groups, or cysteine sulphydryl groups to damage proteins (153)