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Limited Sun Exposure : The body synthesises vitamin D primarily through exposure to sunlight, so individuals living in areas with little sunlight or who spend most of their time indoors face a higher risk of deficiency

Polycythaemia Vera: Treatment with B12 can mask the diagnosis of this blood disorder, so careful monitoring is necessary if B12 is started before a complete diagnosis

Immune surveillance constantly examines the body for abnormal cells then eliminates them before they progress to clinical disease

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Choose based on your primary goal and comfort with injections

A preclinical half-life estimate of under 30 minutes is part of why local placement gets discussed