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Zimmerman HJ, Maddrey WC (1995)

By shifting substrate preference toward lipid metabolism, AX supports sustained energy production during endurance activities, helps delay fatigue, and may improve overall exercise performance

In the retina, GPER activation can promote the survival of retinal neurons and enhance the function of photoreceptors, which is crucial for maintaining a normal visual capacity [114]

A 73 participant venous ulcer study demonstrated 45 percent faster healing in treated groups compared to controls

However, insulin sensitivity and glucose tolerance were maintained, likely owing to an increased conversion of saturated fatty acids (known to cause insulin resistance) to monounsaturated fatty acids mediated by stearoyl-CoA desaturase-1 (SCD1) [52]

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