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Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: Short- and long-term outcome

Primary outcome was a composite of ischemic stroke, systemic embolism, intracranial bleeding, and major extracranial bleeding, while secondary outcomes were ischemic and hemorrhagic events

For accumulation of a drug it is useful to predict that 50% accumulation is reached after one half-life and 75% after 2 half-lives

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