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Kidney slice culture For tissue slice experiments, mice were used for which approval was obtained from the Committee on the Ethics of Animal Experiments of the Erasmus MC, where possible as a left-over from other experiments

In neurodegenerative diseases, inflammation may be triggered by the accumulation of aggregates or modified proteins, which could also be considered DAMPs [7]

During erythropoiesis, the requirement for glycine, succinyl-CoA and iron in heme synthesis is so high that coordination with other metabolic pathways becomes essential to ensure that there are sufficient substrates for heme production as well as for ATP production and the continuation of nutrient metabolism

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tesamorelin is reserved for patients with stronger clinical indications

In June 2021, FDA approved semaglutide as a treatment for chronic weight management in obese or overweight adultsthe first drug approved for such use since 2014