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Commercial production was discontinued in 2008 for non-safety-related business reasons, effectively removing it from the standard pharmaceutical market, although research interest in growth hormone-releasing peptides has continued

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As in T2D, APD-induced increases in circulating insulin are hypothesized to desensitize insulin-sensitive peripheral targets (e.g., liver, skeletal muscle, adipose tissue) over time, resulting in insulin resistance and weight gain 3,4,15