Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW: Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous
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In fact, it has been suggested that reduced exposure to free radicals and increased intake of antioxidant rich foods or antioxidant supplements will enhance the bodys potential to minimize the risk of free radical related health problems.3 Antioxidants such as polyphenols, ascorbic acid, vitamin A, alpha-lipoic acid, thioredoxin, glutathione, melatonin, coenzyme Q, beta carotenoids, alpha-tocopherols as well as antioxidant enzymes including superoxide dismutase, catalase, glutathione-peroxidases , glutathione reductases and glutathione-s-transferases have been widely investigated for the prevention and treatment of diseases resulting from oxidative damage.4, 5, 6, 7 2
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