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At her structured 3-month follow-up visit, her CDAI score indicated she had not reached the target of low disease activity, prompting an increase in her methotrexate dosage to the maximum tolerated dose (Cohen & Mikuls, 2025

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10.1080/15548627.2018.1513758 76 KaruppagounderS

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SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways

In children: developmental delay (sitting and walking), speech delay (learning to talk), spasticity (stiff muscles), and repeated bacterial infections