Ivosidenib (Ag120) is a widely used clinical drug for advanced solid tumors and hematological malignancies
Shiri Levy, a board-certified physician who specializes in managing disorders of the thyroid, parathyroid, pituitary and adrenal glands, lipids, osteoporosis and diabetes
DOI : 10.1199/tab.0142
doi:10.3390/ijms23073607
Research Applications NNMT Enzyme Biology and Inhibition Studies 5-Amino-1MQ serves as a tool for investigating NNMT function: Enzyme Kinetics: Examination of inhibition mechanism, IC determination, selectivity profiling Cellular NNMT Activity: Measurement of 1-MNA production in cells/tissues with/without inhibitor NNMT Expression Regulation: Studies on factors regulating NNMT gene expression Tissue Distribution: Investigation of NNMT expression patterns across tissues and cell types Disease Context: Research on NNMT dysregulation in metabolic disease, cancer, other pathologies Research protocols use biochemical assays, mass spectrometry for 1-MNA quantification, and gene expression analysis
KPV has been studied in models of inflammatory bowel disease (DSS- and TNBS-induced colitis), contact dermatitis, cutaneous vasculitis, asthma, rheumatoid arthritis, and ocular inflammation
