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In addition, an in vivo study proved that CHE exerted specific anticancer effects on concentration adjustment to inhibit the Wnt/-catenin pathway in different lung cancers and facilitate cancer cell apoptosis, inhibiting the proliferation and diminishing the self-renewal capacity of human lung cancer stem cells (HLCSCs) by downregulating -catenin, SOX2, and MYC (Heng and Cheah, 2020

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