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Therefore, the inhibitors developed for the C467 residue of ASCT2 boast the advantages of high specificity and high potency, which can effectively avoid the loss of competitive inhibition by substrate analog inhibitors due to high substrate concentration

These peptides represent a novel class of therapeutic agents that may offer alternatives to traditional treatment approaches for various pathological conditions

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Notably, clinical observations indicate that endocrine therapy resistance is closely associated with oestrogen-dependent redox signal dysregulation mediated by ROS, suggesting that targeting ROS homeostasis may represent a novel breakthrough for reversing drug resistance [127]

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