Nat Rev Rhematol
X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J
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In the nucleus, XBP1s can induce the expression of the GRP78 gene, increase the degradation of endoplasmic reticulum-folded proteins, inhibit the synthesis of new proteins, and induce the transcription of the apoptosis gene CHOP ( This suggests that RA-FLS apoptosis resistance and the persistence of chronic inflammation are associated with ERS
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to investigate how quinone redox metabolism can cause toxicity through GSH depletion