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In humans, OATs 13 are mainly expressed in the basolateral membrane, while OATs 410 are expressed in the apical membranes of the proximal renal tubules

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The process is straightforward once you understand it, but there are a few critical steps where mistakes commonly happen -- and those mistakes can cost you an entire vial

Depending on dose, a fraction of APAP is converted into a highly reactive toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI) by several P450 cytochromes[4]