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Klotho, oxidative stress, and mitochondrial damage in kidney disease

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The NLRP3 inflammasome is activated by lipid peroxidation byproducts such as 4-HNE and MDA produced during ferroptosis, triggering caspase-1-dependent maturation of IL-1/IL-18, which amplifies inflammation and establishes a vicious cycle (127, 131)

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Zhou X.Y., Zhang F., Hu X.T., Chen J., Tang R.X., Zheng K.Y., Song Y.J