When it was recognized that pellagra, a condition marked by diarrhea, dermatitis, dementia, and mortality, could be treated with foods containing NAD+ precursors, particularly vitamin B3, the clinical significance of maintaining NAD+ levels was established in the early 1900s (9). Notably, the skin does not flush with NAD+ injection, in contrast to vitamin B3 (niacin) intake, which also causes this negative effect (10). Low NAD+ levels have recently been associated with a variety of age-related ailments and diseases linked to increased oxidative/free radical damage, including diabetes, heart disease, vascular dysfunction, ischemic brain injury, Alzheimers disease, and vision loss (8, 11-17)
There are no pregnancy restraints, contraindications or precautions listed on the products label when used as directed
The product was delivered quickly and results from its use were almost immediate
An equivalent percentage of infants were exclusively breastfed in each group.[51] Effects in Breastfed Infants Twelve exclusively breastfed infants between 4 and 11 months of age had biochemical, hematological and clinical findings consistent with vitamin B 12 deficiency
Aziz Pirani MD and Dr
Methods 17 (3), 261272
