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Gai Z, Wang T, Visentin M, Kullak-Ublick GA, Fu X, Wang Z

10.1096/fj.08-111005 54 HaddadY

An RCT including 85 women with different indications for ICSI who have been supplemented with AOX daily from the cycle preceding ICSI cycle, versus 85 women who were not given any AOX acting as controls, concluded that AOX therapy did not change clinical or laboratory outcomes (225)

Animal and cellular studies do not reliably predict human outcomes

Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17