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In models of cardiac pressure overload and inflammation, NRF2 activation has been shown to alleviate oxidative injury and improve cardiac function

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Notably, in contrast to the notion that division is the only trigger for GSDMD activation, full-length GSDMD (GSDMD-FL) is also capable of inducing liposome leakage by palmitoyl modification and forming a pore structure similar to that of the GSDMD-NT pore and triggering pyroptosis

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