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Activation of macrophages by microbial products such as LPS, Th1 cytokines such as IL-1, IFN-, or TNF-, or stress such as hypoxia recruits macrophages to the M1 pathway and induces the expression of the iNOS gene, also known as macNOS because it was first discovered in activated macrophages (Molecular and epigenetic basis of, 2015)

PMID: 29375386 DOI: 10.3389/fphar.2017.00987 Sandtner W et al (2014): A quantitative model of amphetamine action on the 5-HT transporter

Ionizing radiation, such as X-rays and gamma rays, has enough energy to remove tightly bound electrons from atoms, creating ions and free radicals

Manjani et al., Effects of acetaminophen on outcomes in patients hospitalized with COVID-19, Chest, doi:10.1016/j.chest.2021.07.992

Funding Japan Society for the Promotion of Science, JP24K18908, Takao Miwa, Uehara Memorial Foundation Ethics declarations Conflict of interest B.S

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