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Mitochondrial DNA (mtDNA) to nuclear DNA (nuDNA) ratio ( K ) in hearts obtained from Ppara / mice fed on regular or tesaglitazar-containing chow (0.5 mol/kg bw) for 6 weeks ( n = 4)

The evolving landscape of obesity pharmacotherapy Nature Reviews Drug Discovery, 2026 1 Obesity pharmacotherapy has moved from weight loss drugs to cardiometabolic disease-modifying therapy Obesity is now framed as a chronic, relapsing, neuroendocrine-metabolic disease, not simply a lifestyle failure

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But they work through entirely separate receptor systems, activating different neural pathways and producing complementary effects when combined

Understanding why RNA viruses may have developed such strategies presents an interesting challenge for future research