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Intramuscular injection may be clinically preferable to oral supplementation in specific situations: For individuals whose bloodwork shows deficiency or insufficiency in B12, vitamin D, or other measurable nutrients, and who have not achieved adequate levels through oral means

But "generally safe" doesn't mean "zero things to know." This guide covers every side effect reported in published research, who should be cautious, how tablets compare to injections, and exactly how to minimise any discomfort