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Current approaches include: Continuous Use Approach: Based on clinical trials that used continuous daily administration for 12-24 weeks without scheduled breaks
These include the bell-shaped dose-response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form
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In addition, considering the important concept, cytoprotection (initially based on the essential consistent ulcerogenic role of NSAIDs agents (25)) can now provide the consistently demonstrated NSAIDs-sphincter failure as an additional clue to further accommodate all of the NSAIDs effects
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Like any medical treatment, these injections can cause side effects, such as pain, swelling, and bruising at the injection site
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