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the two groups had similar clinical features [ALT 5140 vs 2384 U/L], but chronic exposure cases were younger [mean age 3.5 vs 15 years], less likely female [46% vs 82%], and more likely to die [12% vs 2%], however only 22% of them were diagnosed as acetaminophen overdose [37% were "indeterminant"])

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Continuous learning through model evaluation and re-estimation of PK parameters with additional data is critical to further improve precision dosing in applied populations with population-derived models

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Leguisamo NM, Lehnen AM, Machado UF, et al

The rulemaking process stands between any positive recommendation and a pharmacy counter