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There have been extensive animal-based studies conducted on the functioning of IGF-1 in the body

GHKCu is a naturally occurring copper peptide that upregulates collagen I and III, elastin, glycosaminoglycans, and wound-healing pathways while shifting gene expression toward a more youthful pattern and reducing inflammation and oxidative damage

Most researchers don't run IGF-1 LR3 daily indefinitely for this exact reason: the dose-response curve flattens, and the compound's effectiveness per microgram administered drops significantly

However, the research was done in rats, so more human studies are necessary to confirm this potential benefit

Semaglutide works through GLP-1 receptor activation in your brain and gut

The FDA approved an oral semaglutide tablet for weight loss in December 2025