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V.Diez-FraileA.CrielG.SvistunovA

Bedford et al., 2012

Animals were euthanized following anesthesia using isoflurane

We also demonstrate that APR-246 and MQ inhibit ribonucleotide reductase (RNR) in vitro and in living cells

Meanwhile, human clinical data are generally characterized by small sample sizes and short follow-up periods, with inadequate adjustment for confounding factors such as diet and concurrent medications, making it difficult to confirm the long-term efficacy and safety of Clostridium interventions

Membranes were blocked with 5% non-fat milk and incubated with mouse anti-5mC (#61480, Active motif) or anti-5hmC (#39999, Active motif) followed by a horseradish peroxidase-conjugated antibody (Santa Cruz Biotechnology)