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Interestingly, GSK3 inactivation preferentially destabilized the cytoplasmic SIRT7, whereas the nuclear fraction was less prominently affected and even showed comparable levels of stability to the cells without GSK3 inactivation (Supplementary Fig

Garca-Montelongo AM, Montoya-Martnez AC, Morales-Sandoval PH, Parra-Cota FI, de Los Santos-Villalobos S

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Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF alpha