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SOCE deficiency reduces mitochondrial FAO capacity by inhibiting PGC-1/PPAR signaling, while reduced STIM1/Orai1 complex activity exacerbates mitochondrial dysfunction

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It also promotes angiogenesis via VEGF upregulation and wound contraction through actin remodeling

Conclusion The causative agent of the COVID-19 the pandemic, SARS-CoV-2, has caused loss of incomes, economic crises, morbidities, and loss of life worldwide

This selectivity of dexamethasone for system Xc - was further supported by quantification of lipid peroxidation, the hallmark of ferroptosis