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In very rare individuals, especially (but not exclusively) in those with the COL1A1 p.(Arg312Cys) missense variant, spontaneous rupture of large arteries, intracranial aneurysms, and arteriovenous fistulae may occur [5,6,7, 9,10,11,12,13,14, 18,19,20,21,22,23,24,25,26]
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Across the EU, cigarettes are taxed a minimum of 1.92 per pack up to nearly 11 per pack
95% CI: 1.694.61), but among current daily smokers higher pack-equivalent years were not associated with more respiratory symptoms (RR=0.83
Over that same period, national adult smoking rates continued their long decline
