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Consequently, the newly revealed combined NO-system background (i.e., common therapy effect, common NO-response) [59,70] might, for BPC 157 therapy, particularly allocate matching positive-like and negative-like symptoms or indicate specific circuits between the involved brain areas, mesolimbic pathways in the positive-like symptoms and fronto-cortical temporal and cortico-striatal pathways in the negative-like symptoms [1]

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Key publications include Sikiric et al

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10.1016/j.cvsm.2010.05.006