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Pikal MJ, Rigsbee D, Roy ML, et al

Broad Preclinical Data: Extensive animal studies demonstrating effects on tendon healing, muscle repair, gut protection, and neuroprotection provided a scientific veneer to marketing claims

Individuals with Gastrointestinal Disorders: Such as Crohns disease, celiac disease, atrophic gastritis, or those who have had gastric bypass surgery or other stomach/intestinal resections, which can interfere with B12 absorption

Potempa S and Ridley A J (1998) Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor-induced Adherens Junction Disassembly

It is being adopted by the sports medicine community and recently popularized by UFC fighters as well as NFL & NBA player usages