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Ferroptosis is a recently described form of programmed cell death caused by uncontrolled iron dependent lipid peroxidation that distinguishes it from traditional modalities of regulated cell death including apoptosis, necrosis, and autophagy (Li et al., 2020a)

Phytochemistry, pharmacology, and medical uses of Oldenlandia (family Rubaceae): A review

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doi: 10.1016/j.celrep.2021.110028 201 MoorlagSRodriguez-RosalesYAGillardJFanucchiSTheunissenKNovakovicBet al

2017;5(2):e00291 48

This is confirmed by an increase in the production of proinflammatory cytokines IL-1, IL-6 and TNF-, through migration of the transcription factor NF-, the activating protein (AP-1) and cyclooxygenase 2 (COX2) activation [123]