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As a result, the mechanical properties of the scaffolds could influence the differentiation, migration, and proliferation of adjacent cells 53

It is worth mentioning however, that multiple regression analysis highlighted that the Val66Met polymorphism may affect serum levels of BDNF through a complex interaction with gender and in response to specific treatments such as IFN- 48,57 or linked to neurophysiologic response associated with working memory processes 58

10.1002/14651858.cd004655 56 Vidal-AlaballJ.ButlerC

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Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1