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Cancer-associated fibroblast-derived Lumican promotes gastric cancer progression via the integrin 1-FAK signaling pathway

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Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities

I commonly use diindolylmethane (DIM) and sulforaphane from cruciferous vegetables to encourage healthy 2-hydroxylation of estrogen, calcium-D-glucarate to support glucuronidation, magnesium and methylated B vitamins for methylation, and glutathione to help neutralize reactive estrogen metabolites