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The entire data mining, data normalisation, and pathway activity predictions were automated in our in-house R software package as described in Smart et al

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Rights and permissions About this article Cite this article Golabi, M., Kazemi, D., Chadeganipour, A.S

68 The balance among MMPs and TIMPs (tissue inhibitors of metalloproteinases) are important for the regulation of pathogenesis of Matrix metalloproteinases like MMP-1 (interstitial collagenase), MMP-3 (stromelysin-1) and MMP-13 (collagenase 3) plays an essential part in osteoarthritis based on their capability to cleave components of the ECM in articular cartilage