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Several factors can reduce glutathione levels in the body, including: Chronic stress Poor nutrition Smoking Excessive alcohol consumption Lack of sleep Environmental pollution Aging Certain medical conditions Managing these factors may help support healthy glutathione levels over time

Jegasothy, H., Weerakkody, R., Selby-Pham, S

Glutathione is the master antioxidant but there are many other antioxidants which are helpful, including vitamin C, vitamin E, quercetin, beta glucans (eg from medicinal mushrooms), zinc, selenium, and others

However, the sequence variability in GST active sites across species and enzyme families result in differing enzyme activities for various substrates [58]

Modern Extensions: Can We Support Glutathione Even Further