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Young-onset Rectal Cancer: Unique Tumoral Microbiome and Correlation with Response to Neoadjuvant Therapy

Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Tirz initiation Weeks 1-4 Tirzepatide 2.5 mg/week Cagrilintide Not started Notes Confirm tirzepatide GI tolerance first

Recent research has highlighted that reduced levels of sex hormone-binding globulin (SHBG) in the bloodstream are linked to higher susceptibility to obesity, insulin resistance, and diabetes, potentially contributing to broader metabolic imbalances

Plant polyphenols, for example, are well-established hormetins 25,26

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