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In obese mice, the genetic removal of cells expressing high levels of p16 Ink4a (a marker of senescent cells) significantly improved insulin resistance and reduced fat accumulation

Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1

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Similar protective effects were observed in genetically enhanced transgenic mice (STZ, 1 200 mg/kg) for MT, which resulted in a 20-fold increase in MT expression and significant prevention of STZ-induced diabetes [160]

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