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The binding and structural studies of FOXO4-DRI with p53 which are reported in this manuscript are related to the patent
The method of any one of embodiments 1-10, wherein the therapeutic agent is an otoprotectant
What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug
Some investigations have demonstrated that the two compounds, acting as agonists of the GSH antioxidant system, well prevent oxidative stress and reduce heart damage in some animal cardiomyopathy models, for instance, the ISO-induced myocardium infarction model [159, 160]
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they are documented outcomes of a supply chain with no quality infrastructure
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