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On the other hand, decreased production of TCA cycle metabolites such as succinate and fumarate as a result of KGDHC inhibition by CSE treatment might reduce the transcriptional activity of HIFs also under normoxia [44, 54, 55]

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One article states: As you breathe in from a cigarette or vape pen, the air can travel into your digestive tract, causing you to bloat. Nicotine effects on digestion and acid reflux Nicotine is known to relax the lower esophageal sphincter (LES), which can allow stomach acid to move upward (acid reflux), and that can lead to bloating, fullness, belching

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