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doi:10.1074/jbc.M805586200, PMID: 18990698 Borutaite V, Brown GC (2007) Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state

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A meta-analysis of 18 RCTs confirmed PRPs superiority over placebo and corticosteroid injections, highlighting long-term benefits in pain reduction and tendon healing (PMID: 32073993)

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These in vitro findings were confirmed by a recent study focused on 25 CKD patients