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To fine-tune the redox homeostasis that can either prohibit the damage by oxidative distress or maintain the physiologic ROS to sustain normal cellular processes, organisms have evolved a complex antioxidant defense system consisting of both enzymatic and non-enzymatic scavengers

A substantial proportion of microbiota-derived components and metabolites from the gastrointestinal tract are transported to the liver through the portal vein

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10.1161/01.HYP.0000130484.20501.df Hypertension

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Since mitochondria cannot synthesize the negatively charged GSH, SLC25A39 is crucial for maintaining GSH homeostasis within the mitochondria [24]